Transforming growth factor-β (TGF-β)

Definition:

Transforming growth factor-β (TGF-β) is the largest family of secreted growth factors composed of several subfamilies, including TGF-βs, BMPs, GDFs, activins, inhibins, and GDNFs. TGF-β regulates various biological processes including cell proliferation, differentiation, migration, adhesion, apoptosis and extracellular matrix (ECM) production.

References:

[1]. Kubiczkova L, et al . TGF-β - an excellent servant but a bad master. J Transl Med. 2012 Sep 3;10:183. [Content Brief]

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